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產品概述
| 名稱 | 4T1(小鼠乳腺癌細胞) (STR鑒定正確) |
| 別稱 | 4T1-A |
| 背景描述 | 4T1細胞是從410.4瘤株中未經誘變篩得的6-硫鳥嘌噙抗性細胞株。當4T1細胞注射到BALB/c小鼠中時，4T1細胞會自發產生高轉移腫瘤，可轉移到肺、肝、淋巴結和大腦，同時在注射部位形成始發灶，誘導轉移時不需要摘除始發灶。4T1細胞在BALB/c小鼠中的生長與轉移特性與人體中的乳腺癌十分相近，這種腫瘤是人Ⅵ期乳腺癌的動物模型。4T1細胞誘導的腫瘤在手術后及未手術情況下轉移的動力學相近，可以用作手術后及未手術模型。4T1細胞誘導的腫瘤模型跟其他腫瘤模型相比，由于4T1細胞的抗6-硫鳥嘌噙特性，微小的轉移細胞團(少到僅僅1個)也可以在許多遠端器官中檢測到，沒必要數淋巴結或稱重器官。 |
| 種屬 | 小鼠 |
| 組織來源 | 乳腺組織 |
| 生長特性 | 貼壁細胞 |
| 細胞形態 | 上皮細胞樣 |
| 細胞類型 | 腫瘤細胞 |
| 腫瘤類型 | 乳腺癌細胞 |
| 生物安全等級 | 1 |
| 生長培養基 | RPMI-1640＋10% FBS＋1% P/S |
| 推薦傳代比例 | 1:3-1:4 |
| 推薦換液頻率 | 2~3次/周 |
| 凍存條件 | 凍存液：55% 基礎培養基+40%FBS+5%DMSO 溫度：液氮 |
| 培養條件 | 氣相：空氣，95%；CO2，5% 溫度：37℃ |
| 致瘤性 | Yes, forms tumors and metastasizes in BALB/c mice. |
| 保藏機構 | ATCC; CRL-2539 |
STR鑒定
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STR位點信息
18-3 18,19 6-7 12 5-5 14 X-1 24,25 1-2 17 7-1 25.2 8-1 13 1-1 16 19-2 13 15-3 22.3 12-1 16,17 6-4 18 4-2 21.3 3-2 14,15 2-1 16,17 13-1 16.2 11-2 18,19 17-2 15 -
STR鑒定圖
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參考文獻
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作者：Jingjing Guo, Jun Dai, Xiaoluo Peng
期刊：ACS Nano
影響因子 ：18.0270
引用產品：CL-0007
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A photoresponsive and rod-shape nanocarrier: Single wavelength of light triggered photothermal and photodynamic therapy based on AuNRs-capped & Ce6-doped mesoporous silica nanorods(2017/04/01)
作者：Qi Sun, Qing You, Xiaojuan
期刊：Biomaterials
DOI：10.1016/j.biomaterials.2017.01.021
影響因子 ：15.304
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Image-Guided TME-Improving Nano-Platform for Ca2+ Signal Disturbance and Enhanced Tumor PDT(2021/6/24)
作者：Yuping Jiang, Wei Meng, Lijuan Wu
期刊：Advanced Healthcare Materials
影響因子 ：11.0920
引用產品：CL-0007
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Hollow Au–Cu Nanocomposite for Real-Time Tracing Photothermal/Antiangiogenic Therapy(2017/5/2)
作者：Xiaojuan Pang, Xiaoxiao Tan, Jinping Wang
期刊：Advanced Healthcare Materials
影響因子 ：11.0920
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Cell-penetrating corosolic acid liposome as a functional carrier for delivering chemotherapeutic drugs(2020/02/17)
作者：Xuqian Li, Andy Samuel Widjaya, Jingxuan Liu
期刊：Acta Biomaterialia
DOI：10.1016/j.actbio.2020.02.013
影響因子 ：10.6330
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BSA–Bioinspired Gadolinium Hybrid-Functionalized Hollow Gold Nanoshells for NIRF/PA/CT/MR Quadmodal Diagnostic Imaging-Guided Photothermal/Photodynamic Cancer Therapy(2017/10/31)
作者：Qing You, Qi Sun, Meng Yu
期刊：ACS Applied Materials & Interfaces
影響因子 ：10.3830
引用產品：CL-0007
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Injectable, Biodegradable, Thermosensitive Nanoparticles-Aggregated Hydrogel with Tumor-Specific Targeting, Penetration, and Release for Efficient Postsurgical Prevention of Tumor Recurrence(2019/05/09)
作者：Huiming Liu, Xiaoguang Shi, Di Wu
期刊：ACS Applied Materials & Interfaces
影響因子 ：10.3830
引用產品：CL-0007
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RETURN TO ISSUEPREVRESEARCH ARTICLENEXTInjectable, Biodegradable, Thermosensitive Nanoparticles-Aggregated Hydrogel with Tumor-Specific Targeting, Penetration, and Release for Efficient Postsurgical Prevention of Tumor Recurrence(2019/05/09)
作者：Huiming Liu, Xiaoguang Shi, Di Wu, Frewein Kahsay Khshen
期刊：ACS Applied Materials & Interfaces
影響因子 ：10.383
引用產品：CL-0007
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Self-Assembly of an Antitumor Dipeptide Induced Near-Infrared Fluorescence and Improved Stability for Theranostic Applications(2021/07/06)
作者：Weifeng Lin, Yingchun Yang, Yang Lei
期刊：ACS Applied Materials & Interfaces
影響因子 ：10.3830
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Persistent Luminescence Nanoplatform with Fenton-like Catalytic Activity for Tumor Multimodal Imaging and Photoenhanced Combination Therapy(2020/05/15)
作者：Shuqi Wu, Zihan Qiao, Yang Li
期刊：ACS Applied Materials & Interfaces
影響因子 ：10.3830
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MSOT/CT/MR imaging-guided and hypoxia-maneuvered oxygen self-supply radiotherapy based on one-pot MnO2-mSiO2@Au nanoparticles(2019/03/28)
作者：Siyu Wang, Qing You, Jinping Wang
期刊：Nanoscale
影響因子 ：8.307
引用產品：CL-0007
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A single-light triggered and dual-imaging guided multifunctional platform for combined photothermal and photodynamic therapy based on TD-controlled and ICG-loaded CuS@mSiO2(2016/12/22)
作者：Qing You, Qi Sun, Jinping Wang
期刊：Nanoscale
影響因子 ：8.307
引用產品：CL-0007
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A triple-synergistic strategy for combinational photo/radiotherapy and multi-modality imaging based on hyaluronic acid-hybridized polyaniline-coated WS2 nanodots(2017/03/28)
作者：Jinping Wang, Xiaojuan Pang, Xiaoxiao Tan
期刊：Nanoscale
影響因子 ：8.307
引用產品：CL-0007
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A tungsten nitride-based degradable nanoplatform for dual-modal image-guided combinatorial chemo-photothermal therapy of tumors(2018/12/27)
作者：Cheng Zhang,Shibo Wang,Zhaoxia Chen
期刊：Nanoscale
影響因子 ：8.307
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A multimodal strategy of Fe3O4@ZIF-8/GOx@MnO2 hybrid nanozyme via TME modulation for tumor therapy(2021/09/15)
作者：Yu Zhang, Yifeng Yang, Jinsheng Shi
期刊：Nanoscale
影響因子 ：8.307
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Micelle nanovehicles for co-delivery of Lepidium meyenii Walp. (maca) polysaccharide and chloroquine to tumor-associated macrophages for synergistic cancer immunotherapy(2021/08/25)
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期刊：International Journal Of Biological Macromolecules
DOI：10.1016/j.ijbiomac.2021.08.155
影響因子 ：8.025
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UCPs/Zn2GeO4:Mn2+/g-C3N4 heterojunction engineered injectable thermosensitive hydrogel for oxygen independent breast cancer neoadjuvant photodynamic therapy(2021/01/13)
作者：Linchao Zhang, Manli Yang, Yishun Ji
期刊：Biomaterials Science
影響因子 ：7.590
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Oxygen-rich chemotherapy via modified Abraxane to inhibit the growth and metastasis of triple-negative breast cancer(2018/11/13)
作者：Lingtong Meng, Shaoju Gan, Ya Zhou
期刊：Biomaterials Science
影響因子 ：7.590
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Photosensitizer loaded PEG-MoS?–Au hybrids for CT/NIRF imaging-guided stepwise photothermal and photodynamic therapy(2017/02/24)
作者：Li Liu, Jinping Wang, Xiaoxiao Tan
期刊：Journal of materials chemistry B
影響因子 ：7.571
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NIRF/PA/CT multi-modality imaging guided combined photothermal and photodynamic therapy based on tumor microenvironment-responsive nanocomposites(2018/06/18)
作者：Li Liu, Jinping Wang, Qing You
期刊：Journal of Materials chemistry. B
影響因子 ：7.571
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Magnetically-targeted and near infrared fluorescence/magnetic resonance/photoacoustic imaging-guided combinational anti-tumor phototherapy based on polydopamine-capped magnetic Prussian blue nanoparticles(2018/04/06)
作者：Yidan Wang, Xiaojuan Pang, Jinping Wang
期刊：Journal of Materials Chemistry B
影響因子 ：7.571
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Synergistic Theranostics of Magnetic ResonanceImaging and Photothermal Therapy of Breast CancerBased on the Janus Nanostructures Fe3O4-Aushell-PEG(2021/09/16)
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影響因子 ：7.0330
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期刊：Talanta
DOI：10.1016/j.talanta.2020.121435
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Free paclitaxel-loaded E-selectin binding peptide modified micelle self-assembled from hyaluronic acid-paclitaxel conjugate inhibit breast cancer metastasis in a murine model(2017/05/31)
作者：Xiaofeng Han, Xuerong Dong, Jing Li
期刊：International Journal Of Pharmaceutics
DOI：10.1016/j.ijpharm.2017.05.063
影響因子 ：6.510
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Interface-Engineered Paclitaxel-Based Hollow Mesoporous Organosilica Nanoplatforms for Photothermal-Enhanced Chemotherapy of Tumor(2021/11/05)
作者：Chunxi Qian, Bandar Alhamyari, Xiaofei Tang
期刊：Molecular Pharmaceutics
DOI：10.1021/acs.molpharmaceut.1c00735
影響因子 ：5.3640
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Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells(2020/8/19)
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影響因子 ：4.2190
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Xiaoyao Kangai Jieyu Fang, a Chinese Herbal Formulation, Ameliorates Cancer-Related Depression Concurrent with Breast Cancer in Mice via Promoting Hippocampal Synaptic Plasticity(2018/11/18)
作者：Pan Meng, Yuanshan Han, Qin Yang
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